BPC-157 Dosage Calculator
A 15-amino-acid peptide studied almost entirely in rodents. No published human trial supports any of the injury-healing uses it is sold for, and no dose per kilogram of body weight exists for people.
Written by Kashif Khan, who builds and maintains this site and is not a clinician. Every figure links to its primary source.
Not approved, and not lawfully compoundable
The regulatory position is widely misreported, in both directions. BPC-157 was added to the FDA's 503A Category 2 list (substances posing significant safety risks) on 29 September 2023. It was removed from Category 2 on 22 April 2026 — but only because the nominators withdrew their nominations, and removal did not move it to Category 1. On the FDA's own Category 2 page it now appears solely under “nominated but withdrawn”, and it is absent from all three categories of the nominated-substances list. Sitting on no FDA list means it still fails the statutory test for compounding under section 503A. On 23 July 2026 the Pharmacy Compounding Advisory Committee voted 8–6 to recommend adding it to the 503A bulks list for ulcerative colitis; that vote is advisory only, no rulemaking has occurred, and it does not make the substance legal. Anyone telling you “BPC-157 is Category 2” or “BPC-157 is now legal” is wrong.
No approved human dose exists for this compound in any country. The figures below are the doses used in named published studies, reproduced for reference only. Doses given to rats or mice do not convert to a human dose. The FDA has stated that labelling a product “research use only” or “not for human consumption” does not change its legal status when the seller's own marketing shows it is intended for people.
Anti-doping: Prohibited at all times. Classified under WADA class S0. USADA states plainly: “Because BPC-157 has not been extensively studied in humans, it is unknown if there is a safe dose.”
Key facts
- Molecular weight
- 1,419.5 DaSequence GEPPPGKPADDAGLV. The FDA has separately flagged that “BPC-157” is a common name, not a United States Adopted Name, and that products sold under it differ in salt form and active moiety.
- Half-life
- Not published. No accessible human pharmacokinetic study reports one, so any specific figure quoted elsewhere has no primary source behind it.
- Also sold as
- Body Protection Compound 157, PL 14736, Pentadecapeptide BPC 157
Doses used in published studies
These are reproduced for reference. They are not recommendations, and an animal dose in mg/kg does not convert to a human dose.
How good is the evidence?
Hundreds of rodent papers, overwhelmingly from a single research group in Zagreb. A 2025 systematic review of the orthopaedic literature screened 544 articles published between 1993 and 2024 and found 36 that qualified: 35 preclinical and one clinical — a 17-patient retrospective chart review of knee injections, with no control group and no dose reported. Its finding on safety was that no clinical safety data exist at all. Reviews describe the ulcerative colitis programme (PL 14736) as having reached phase 2, but it was never published in full, and a 2015 phase 1 study of oral BPC-157 has sat at registry status “unknown” ever since without posting results. A 2026 review in the American Journal of Sports Medicine states the position bluntly: indications, dosing, frequency and duration all remain unknown.
Common questions
Sources
Every number on this page comes from one of the documents below. Where no reliable source exists, the page says so instead of filling the gap.
- RegulatorFDA· 2026-05-14Bulk Drug Substances Nominated for Use in Compounding Under Section 503A
- RegulatorFDACertain Bulk Drug Substances for Use in Compounding May Present Significant Safety Risks
- RegulatorFDA· 2026-07July 23–24, 2026 Meeting of the Pharmacy Compounding Advisory Committee
- RegulatorUSADABPC-157 is a Prohibited Peptide
- RegulatorWorld Anti-Doping Agency· 2026WADA 2026 Prohibited List
- Published studyPubMed CentralSikirić P et al. Stable gastric pentadecapeptide BPC 157 — a review of the rodent literature
- Published studyFrontiers in Pharmacology 2022;13:1026182· 2022-12He L, Feng D, Guo H, et al. Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157 in rats and dogs
- Published studyHSS Journal 2025;21(4):485–95· 2025-11Vasireddi N, Hahamyan H, Salata MJ, et al. Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review
- Published studyAlternative Therapies in Health and Medicine 2021;27(4):8–13· 2021-07Lee E, Padgett B. Intra-Articular Injection of BPC 157 for Multiple Types of Knee Pain
- Published studyAmerican Journal of Sports Medicine 2026;54(1):223–9· 2026-01Mayfield CK, Bolia IK, Feingold CL, et al. Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians
- Published studyJoint Diseases and Related Surgery 2026;37(3):822–37· 2026-07Biçer O, Adanir O, Güleryüz Y, et al. Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: a histopathological and biomechanical study
- ReferenceClinicalTrials.gov· 2015-10NCT02637284 — PCO-02 (oral BPC-157) phase 1 safety and pharmacokinetics in healthy volunteers
- ReferenceClinicalTrials.gov· 2027-01NCT07803250 — Impact of BPC-157 on recovery from rotator cuff repair surgery (phase 1, University of Arkansas)
- RegulatorFDA / CDER· 2005-07Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers — Guidance for Industry (Table 1, body surface area conversion factors)
- ReferenceNIH / National Center for Biotechnology InformationPubChem compound records (molecular weights and formulae)